- Domperidone 30mg+
- Pantoprazole 40 mg
- Peptic Ulcers.
- Reflux Oesophagitis.
- As one component therapy for Helicobacter Pylori infection*.
- Zollinger-Ellison syndrome** (a rare condition caused by gastrin secreting tumours.
- NSAID Induced Dyspepsia.
Terminology and Definition:-
- Peptic Ulcers:- Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, first part of the small intestine or sometimes the lower esophagus. An ulcer in thestomach is called a gastric ulcer, while that in the first part of the intestines is a duodenal ulcer.
- GERD:- Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the lining of your esophagus.
- Zollinger-Ellison syndrome :- A condition in which a gastrin-secreting tumour or hyperplasia of the islet cells in the pancreas causes overproduction of gastric acid, resulting in recurrent peptic ulcers.
- NSAID Induced Dyspepsia:- Non-steroidal anti-inflammatory drugs (NSAIDs) induced epigastric pain or discomfort leads to peptic Ulcers.
MODE OF ACTION:-
- Pantoprazole:- Inhibit the final step in gastric acid production. In the gastric parietal cell of the stomach, pantoprazole covalently binds to the H+/K+ ATP pump to inhibit gastric acid and basal acid secretion. The covalent binding prevents acid secretion for up to 24 hours and longer.